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KMID : 1001020030010010095
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Journal of Urologic Oncology
2003 Volume.1 No. 1 p.95 ~ p.99
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Comparison of the NMP-22 Test, BTA TRAK Assay and Cytology in the Detection of Bladder Cancer
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Lee Kang-Hyun
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Abstract
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Purpose: Both BTA TRAK assay and NMP22 test have shown a sensitivity superior to urine cytology in the detection of bladder cancer. The purpose of this study was to evaluate the clinical performance of the BTA TRAK assay and NMP 22 test and to compare these tests with that of voided urine cytology in the detection of bladder cancer.
Materials and Methods: BTA TRAK assay, NMP22 test and urine cytology were performed for two groups of patients. Bladder cancer group was comprised of patients with histologically confirmed active bladder cancer. The second group of patients had a history of bladder cancers but were considered to have no evidence of disease on the basis of cystoscopic evaluation of bladder and/or biopsy. Sensitivity was determined in urine samples from patients with histologically confirmed bladder cancer. Specificity was determined in samples from patients who had a history of bladder cancer but no current evidence of disease.
Results: The sensitivities of NMP 22 test (79.2%) and BTA TRAK assay (87.5%) was significantly higher than that of voided urine cytology (45.8%). According to grade, the sensitivity of BTA TRAK assay was significantly higher than that of voided urine cytology in urine samples from patients with grade 1 bladder cancer. The specificity of NMP 22 test and that of BTA TRAK assay were 80% respectively in patients who had a history of bladder cancer but no current evidence of disease.
Conclusions: Both NMP 22 test and BTA TRAK assay are superior to voided urine cytology in the detection of bladder cancer and there is no significant difference between NMP 22 test and BTA TRAK assay. The results of this study indicate that both NMP 22 test and BTA TRAK assay are useful adjuncts to cystoscopy and useful monitoring tools of bladder cancer.
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KEYWORD
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Bladder cancer, NMP 22 test, BTA TRAK assay, Cytology
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